Extraintestinal pathogenic isolates ofEscherichia colido not possess active IgA1, IgA2, sIgA or IgG proteases
نویسندگان
چکیده
منابع مشابه
Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases.
To understand more about the factors influencing the cleavage of immunoglobulin A1 (IgA1) by microbial IgA1 proteases, a recombinant human IgA2/IgA1 hybrid molecule was generated. In the hybrid, termed IgA2/A1 half hinge, a seven-amino-acid sequence corresponding to one half of the duplicated sequence making up the IgA1 hinge was incorporated into the equivalent site in IgA2. Insertion of the I...
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The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such e...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2008
ISSN: 0928-8244,1574-695X
DOI: 10.1111/j.1574-695x.2008.00393.x